Clinical implications of the stress response.

MicroRNA-regulated stress response in cancer and its clinical implications

During the process of tumorigenesis, the microenvironments of cancer cells are constantly undergoing changes and remodeling. Such changes and remodeling can lead to shortage of blood supply, reactive immune responses and damage to cellular components (Fig. 1). Any environmental fluctuations leading to deviations from physiological homeostasis are considered as stress to cancer cells. It is well...

Clinical implications of cellular stress responses.

Cellular stress response is a reaction to changes or fluctuations of extracellular conditions that damage the structure and function of macromolecules. Different stressors trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Inability to repair the damage o...

Oxidative Stress and its Role in Female Infertility and Assisted Reproduction: Clinical Implications

Reactive oxygen species (ROS) are involved in physiological functions and act as mediators in various signaling processes. Elevated or sustained generation of free radicals and non radical species derived from free radicals can lead to an imbalance in the intracellular redox homeostasis. Normally, any excess levels of reactive radical and nonradical species generated are intercepted by antioxid...

Alcohol Use Disorders: Implications for the Clinical Toxicologist

Alcohol use disorders (AUDs) are a health problem of high prevalence in most communities and such problems account for 5% of the total burden of disease worldwide. Clinical toxicologists are commonly required to treat patients having AUDs and associated drug/alcohol-related harm. There have been recent changes to some of the diagnostic criteria (notably in DSM V) relevant to AUDs, with older te...

Oxidative stress: clinical implications in cardiac surgery.